Diversity Committee Report: Healthcare Disparities in Head and Neck Cancer
Randal A. Otto, MD Professor and Chairman Thomas Walthall Folbre, MD Endowed Chair in Otolaryngology University of Texas, San Antonio for the AAO-HNS Committee Although treatment for head and neck cancer has seen tremendous technological advances in surgery, radiation therapy, and chemotherapy, unfortunately we have not achieved an appreciable change in survival for several decades. This promises to change as we shift from simply recognizing tumors by their histologic characteristics to a better understanding of their pathogenesis at the molecular level. This alone, however, will not suffice. To illustrate, while we know that cancer incidence and death rates differ among racial and ethnic groups and the data demonstrate higher death rates in blacks than in whites, there is no consensus as to the etiology of these differences.1-5 Indeed, laryngeal cancer mortality in African-American men is more than double that in white men and ranks second only to prostate cancer mortality in magnitude of disparity.1,2 Similar data regarding the Hispanic population is scarce but also may represent areas of healthcare disparities and gaps in our understanding.6-8 Although some reports note differences in access to care, stage at diagnosis, insurance status, and attitudes of health providers playing an important role in these disparities, the degree to which significant biological factors account for the disparities remains largely undefined and mandates elucidation.8,9 This is substantiated by the National Cancer Institute Black/White Cancer Survival Study launched in the 1980s. This demonstrated poorer survival for black versus white patients with colon, breast, uterine, bladder tumors, and head and neck cancers after adjustment for both clinical and socioeconomic characteristics.10-12 These findings support the concept that some cancers may be biologically more aggressive in blacks than whites. Understanding of the nuances that may combine the social, economic, and biologic factors rendering healthcare disparities is beginning to emerge.8,13-16 In 2009 Settle, et al., the University of Maryland Marlene and Stewart Greenebaum Cancer Center in Baltimore and Harvard Medical School’s Dana-Farber Cancer Institute in Boston reported a higher incidence (nine-fold) of human papillomavirus (HPV)-related head and neck cancers in caucasians versus blacks.15 This represented a somewhat unexpected explanation for the poor survival of blacks with head and neck cancer. After testing tumor samples from 201 patients for the presence of HPV-16, which has been definitively linked to oropharyngeal and cervical cancers, these authors discovered more whites were found to have the HPV-positive tumors and more whites than blacks were still alive five years after their diagnoses. Specifically, 80 percent of whites with HPV-positive tumors in the study were alive five years after diagnosis compared with fewer than 40 percent of both whites and blacks with HPV-negative tumors. There were too few blacks with HPV-positive tumors to determine their survival rate. Subsequently Weinberger, et al., reported none of their black patients were likely to have HPV-active disease compared to 21 percent of their white patients, and patients with HPV-active cancers had an improved overall five-year survival of 59.7 percent versus HPV-negative and HPV-inactive patients of 16.9 percent (P=.003)14 In an editorial in Cancer Prevention Research, hematologist-oncologist Otis Brawley, the chief medical officer of the American Cancer Society, stated that sexual habits in young teens may explain why blacks and whites have such different rates of HPV-positive tumors.17 According to a study by the Centers for Disease Control and Prevention, adolescent blacks are much more likely than whites to have genital sex before they have oral sex. Acquiring a genital HPV infection may provoke an immune response that protects a person from a subsequent oropharyngeal HPV infection because the immune response acts like a vaccination.17-18 Brawley points out that when it comes to cancer research, it’s important to look more than skin-deep and that we should always be thinking about sociocultural factors that can explain black-white differences, instead of just ending the discussion at race. It is the duty and obligation of our specialty and society to understand these differences if we wish to improve the outcomes. To paraphrase Einstein, to continue to do the same thing and expect different results is unsound. References 1. Ries LAG, Melbert D, Krapcho M, et al., editors. SEER Cancer Statistics Review, 1975–2005, National Cancer Institute. Bethesda, MD: National Cancer Institute; 2008. [Accessed: October 15, 2008]. http://seer.cancer.gov/csr/1975_2005/ 2. American Cancer Society. Cancer Facts and Figures for African Americans 2007–2008. Atlanta, GA: American Cancer Society; 2007. 1-27 3. Ward E, Jemal A, Cokkinides V, et al. Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin. 2004;54(2):78–93. [PubMed] 4. Bach PB, Schrag D, Brawley OW, Galaznik A, Yakren S, Begg CB. Survival of blacks and whites after a cancer diagnosis. JAMA. 2002;287(16):2106–2113. [PubMed] 5. Molina, M. A., Cheung, M. C., Perez, E. A., Byrne, M. M., Franceschi, D., Moffat, F. L., Livingstone, A. S., Goodwin, W. J., Gutierrez, J. C. and Koniaris, L. G. (2008), African-American and poor patients have a dramatically worse prognosis for head and neck cancer. Cancer, 113: 2797–280 6. doi: 10.1002/cncr.238896. Franco EL, Dib LL, Pinto DS, Lombardo V, Contesini H. Race and gender influences on the survival of patients with mouth cancer. J Clin Epidemiol. 1993;46(1):37–46. [PubMed] 7. Harris GJ, Clark GM, Von Hoff DD. Hispanic patients with head and neck cancer do not have a worse prognosis than Anglo-American patients. Cancer. 1992;69(4):1003–1007. [PubMed] 8. Chen LM, Li G, Reitzel LR, Pytynia KB, Zafereo ME, Wei Q, Sturgis EM. Matched-pair analysis of race or ethnicity in outcomes of head and neck cancer patients receiving similar multidisciplinary care. Cancer Prev Res (Phila). 2009 Sep;2(9):782-91. Epub 2009 Sep 8 9. Gourin CG, Podolsky RH. Racial disparities in patients with head and neck squamous cell carcinoma. Laryngoscope. 2006 Nov;116(11):2098 10. Hunter CP, Redmond CK, Chen VW et al. Breast cancer: factors associated with stage at diagnosis in black and white women. Black/ white Cancer Survival Study group. J Natl Cancer Inst 1993;85:1129-37 11. Eley JW, Hill HA, Chen VW. Racial differences in survival from breast cancer. Results in survival from breast cancer. Results of the National Cancer Institute Blake / White Cancer Survival Study. JAMA 1994;947-54 12. Howard J, Hankey BF, Greenberg RS, et al, A collaborative study of differences in the survival rates of black patients and white patients with cancer. Cancer. 1992;69:2349-2360 13. Ragin CC, Langevin SM, Marzouk M, Grandis J, Taioli E. Determinants of head and neck cancer survival by race. Head Neck. 2010;1-9 14. Weinberger PM, Merkley MA, Khichi SS, Lee JR, Psyrri A, Jackson LL, Dynan WS. Human papillomavirus-active head and neck cancer and ethnic health disparities. Laryngoscope. 2010 Aug; 120(8):1531-7 15. Settle K, Posner MR et al Racial Survival Disparity in Head and Neck Cancer Results from Low Prevalence of Human Papilloma Infection in Black Oropharyngeal Cancer Patients; Cancer Prev Res 2009;2(9) OF1-6 16. Chernock RD, Zhang Q, El-Mofty SK et al; Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx A comparative Study in Whites and African Americans. Arch Oto HNS 2011:137(2):163-169 17. Brawley, O; Cancer prevention research 2009, 2(9) Sept 2009 OF1-3 18. Brawley OW. Population categorization and cancer statistics. Cancer Metastasis Rev 2003; 22:11-9
Randal A. Otto, MD
Professor and Chairman
Thomas Walthall Folbre, MD Endowed Chair in Otolaryngology
University of Texas, San Antonio for the AAO-HNS Committee
Although treatment for head and neck cancer has seen tremendous technological advances in surgery, radiation therapy, and chemotherapy, unfortunately we have not achieved an appreciable change in survival for several decades. This promises to change as we shift from simply recognizing tumors by their histologic characteristics to a better understanding of their pathogenesis at the molecular level. This alone, however, will not suffice. To illustrate, while we know that cancer incidence and death rates differ among racial and ethnic groups and the data demonstrate higher death rates in blacks than in whites, there is no consensus as to the etiology of these differences.1-5
Indeed, laryngeal cancer mortality in African-American men is more than double that in white men and ranks second only to prostate cancer mortality in magnitude of disparity.1,2 Similar data regarding the Hispanic population is scarce but also may represent areas of healthcare disparities and gaps in our understanding.6-8 Although some reports note differences in access to care, stage at diagnosis, insurance status, and attitudes of health providers playing an important role in these disparities, the degree to which significant biological factors account for the disparities remains largely undefined and mandates elucidation.8,9
This is substantiated by the National Cancer Institute Black/White Cancer Survival Study launched in the 1980s. This demonstrated poorer survival for black versus white patients with colon, breast, uterine, bladder tumors, and head and neck cancers after adjustment for both clinical and socioeconomic characteristics.10-12 These findings support the concept that some cancers may be biologically more aggressive in blacks than whites. Understanding of the nuances that may combine the social, economic, and biologic factors rendering healthcare disparities is beginning to emerge.8,13-16
In 2009 Settle, et al., the University of Maryland Marlene and Stewart Greenebaum Cancer Center in Baltimore and Harvard Medical School’s Dana-Farber Cancer Institute in Boston reported a higher incidence (nine-fold) of human papillomavirus (HPV)-related head and neck cancers in caucasians versus blacks.15 This represented a somewhat unexpected explanation for the poor survival of blacks with head and neck cancer.
After testing tumor samples from 201 patients for the presence of HPV-16, which has been definitively linked to oropharyngeal and cervical cancers, these authors discovered more whites were found to have the HPV-positive tumors and more whites than blacks were still alive five years after their diagnoses. Specifically, 80 percent of whites with HPV-positive tumors in the study were alive five years after diagnosis compared with fewer than 40 percent of both whites and blacks with HPV-negative tumors. There were too few blacks with HPV-positive tumors to determine their survival rate.
Subsequently Weinberger, et al., reported none of their black patients were likely to have HPV-active disease compared to 21 percent of their white patients, and patients with HPV-active cancers had an improved overall five-year survival of 59.7 percent versus HPV-negative and HPV-inactive patients of 16.9 percent (P=.003)14
In an editorial in Cancer Prevention Research, hematologist-oncologist Otis Brawley, the chief medical officer of the American Cancer Society, stated that sexual habits in young teens may explain why blacks and whites have such different rates of HPV-positive tumors.17 According to a study by the Centers for Disease Control and Prevention, adolescent blacks are much more likely than whites to have genital sex before they have oral sex. Acquiring a genital HPV infection may provoke an immune response that protects a person from a subsequent oropharyngeal HPV infection because the immune response acts like a vaccination.17-18 Brawley points out that when it comes to cancer research, it’s important to look more than skin-deep and that we should always be thinking about sociocultural factors that can explain black-white differences, instead of just ending the discussion at race.
It is the duty and obligation of our specialty and society to understand these differences if we wish to improve the outcomes. To paraphrase Einstein, to continue to do the same thing and expect different results is unsound.
References
1. | Ries LAG, Melbert D, Krapcho M, et al., editors. SEER Cancer Statistics Review, 1975–2005, National Cancer Institute. Bethesda, MD: National Cancer Institute; 2008. [Accessed: October 15, 2008]. http://seer.cancer.gov/csr/1975_2005/ |
2. | American Cancer Society. Cancer Facts and Figures for African Americans 2007–2008. Atlanta, GA: American Cancer Society; 2007. 1-27 |
3. | Ward E, Jemal A, Cokkinides V, et al. Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin. 2004;54(2):78–93. [PubMed] |
4. | Bach PB, Schrag D, Brawley OW, Galaznik A, Yakren S, Begg CB. Survival of blacks and whites after a cancer diagnosis. JAMA. 2002;287(16):2106–2113. [PubMed] |
5. | Molina, M. A., Cheung, M. C., Perez, E. A., Byrne, M. M., Franceschi, D., Moffat, F. L., Livingstone, A. S., Goodwin, W. J., Gutierrez, J. C. and Koniaris, L. G. (2008), African-American and poor patients have a dramatically worse prognosis for head and neck cancer. Cancer, 113: 2797–280 |
6. | doi: 10.1002/cncr.238896. Franco EL, Dib LL, Pinto DS, Lombardo V, Contesini H. Race and gender influences on the survival of patients with mouth cancer. J Clin Epidemiol. 1993;46(1):37–46. [PubMed] |
7. | Harris GJ, Clark GM, Von Hoff DD. Hispanic patients with head and neck cancer do not have a worse prognosis than Anglo-American patients. Cancer. 1992;69(4):1003–1007. [PubMed] |
8. | Chen LM, Li G, Reitzel LR, Pytynia KB, Zafereo ME, Wei Q, Sturgis EM. Matched-pair analysis of race or ethnicity in outcomes of head and neck cancer patients receiving similar multidisciplinary care. Cancer Prev Res (Phila). 2009 Sep;2(9):782-91. Epub 2009 Sep 8 |
9. | Gourin CG, Podolsky RH. Racial disparities in patients with head and neck squamous cell carcinoma. Laryngoscope. 2006 Nov;116(11):2098 |
10. | Hunter CP, Redmond CK, Chen VW et al. Breast cancer: factors associated with stage at diagnosis in black and white women. Black/ white Cancer Survival Study group. J Natl Cancer Inst 1993;85:1129-37 |
11. | Eley JW, Hill HA, Chen VW. Racial differences in survival from breast cancer. Results in survival from breast cancer. Results of the National Cancer Institute Blake / White Cancer Survival Study. JAMA 1994;947-54 |
12. | Howard J, Hankey BF, Greenberg RS, et al, A collaborative study of differences in the survival rates of black patients and white patients with cancer. Cancer. 1992;69:2349-2360 |
13. | Ragin CC, Langevin SM, Marzouk M, Grandis J, Taioli E. Determinants of head and neck cancer survival by race. Head Neck. 2010;1-9 |
14. | Weinberger PM, Merkley MA, Khichi SS, Lee JR, Psyrri A, Jackson LL, Dynan WS. Human papillomavirus-active head and neck cancer and ethnic health disparities. Laryngoscope. 2010 Aug; 120(8):1531-7 |
15. | Settle K, Posner MR et al Racial Survival Disparity in Head and Neck Cancer Results from Low Prevalence of Human Papilloma Infection in Black Oropharyngeal Cancer Patients; Cancer Prev Res 2009;2(9) OF1-6 |
16. | Chernock RD, Zhang Q, El-Mofty SK et al; Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx A comparative Study in Whites and African Americans. Arch Oto HNS 2011:137(2):163-169 |
17. | Brawley, O; Cancer prevention research 2009, 2(9) Sept 2009 OF1-3 |
18. | Brawley OW. Population categorization and cancer statistics. Cancer Metastasis Rev 2003; 22:11-9 |