Online Exclusive: Evidence Gaps: Prioritizing Our Research “To Do” List
By Scott E. Brietzke, MD, MPH, OREBM Committee Chair Which Chore to Do First? The “dog days” of summer are upon us and that “to do” list of yard work is growing: fix the gate, paint the fence, plant that tree in the corner of the front yard. Let’s not kid ourselves, it’s all work, right? We would certainly take watching the game with the AC on in place of any of it. But if we are going to work in the yard on a Saturday afternoon, planting that tree (that the neighbors will surely notice) certainly sounds better than fixing that old gate and painting that fence. For those who perform research, there is nothing greater than discovering something new and exciting, or publishing a paper on the “latest and greatest” thing everyone will be talking about. After all, who doesn’t want their work to be useful and interesting? But should the “latest and greatest” be what drives which research areas are pursued, instead of perhaps targeting the specific areas where new knowledge or data on comparative effectiveness would be more beneficial to our patients and our specialty? When winter comes around again and the leaves have fallen off the tree we planted (although, we did get some nice comments from the neighbors) we are sure going to wish we had made the time to paint that darn fence and fix that old gate! The Outcomes Research and Evidence-Based Medicine (OREBM) Committee of the American Academy of Otolaryngology—Head and Neck Surgery Foundation strives to assist our specialty in this endeavor. Its formal stated charge is “to serve as a repository of expertise on health services research and evidence-based medicine, including outcomes and effectiveness research generally and specifically in otolaryngology-head and neck surgery; to advise and support other Academy and Foundation committees on outcomes and clinical effectiveness; to liaise with the Patient Safety and Quality Improvement Committee on research aspects of the development of clinical practice guidelines; to develop and maintain educational materials; instructional courses; and Annual Meeting miniseminars in these areas, including an Outcomes Primer; and to develop and maintain a prioritized list of project areas suitable for research on outcomes and clinical effectiveness.” With this charge in mind, the OREBM aims to: Highlight relevant, current research data that can assist the otolaryngologist with patient decision-making and Guide research efforts into clinical areas that will most benefit our specialty based on identified gaps in evidence and emerging clinical importance. Developing the ‘To Do’ List: Where Are the Evidence Gaps? The OREBM Committee has spent considerable time pondering that issue for otolaryngology as a specialty. We have made it our task to reflect on our own practices and consider what areas are in most need of future data (i.e., evidence gaps) to help improve our evidence-based clinical decision-making. We developed a selected “to do” list of prioritized areas for future study in Table 1*. Note that only some areas of otolaryngology are listed—we are currently well represented with pediatric otolaryngologists, rhinologists, laryngologists, and sleep surgeons on the committee. We are in need of more neuro-otologists, head and neck surgeons, and facial plastic surgeons to join us. If this is your area of expertise and interest, please consider participation in the OREBM Committee. The more people who look around the “yard” the more complete our “to do” list will be and the better the “yard” will be. In addition to pondering evidence gaps, the OREBM Committee has been considering and attempting to identify clinical areas that may benefit from compiling and critically analyzing the currently available data in the form of a systematic review or meta-analysis. These efforts may lead to future studies and/or help sharply develop clinical areas where true evidence gaps lie. The completion of a high-quality meta-analysis is not a simple task. Some committee members have been selected, after an academy-wide competitive search (anyone can apply), for sponsorship to attend the International Cochrane Collaboration Colloquium Meeting in October that will include training in advanced meta-analysis techniques. The requirement for receiving this support is a resulting submission of a completed meta-analysis for publication in Otolaryngology-Head and Neck Surgery. Thus, Academy members can expect to see more high-quality meta-analyses in our journal in the future. How to Steer Research Effort into Targeted Areas? Quality research requires talent, time, and financial support. The Academy and the OREBM Committee are exploring ways to tie financial support to study prioritized research areas for the benefit of future patients and our specialty as a whole. Stay tuned for more on this topic. In conclusion, we hope you agree that even some of those less exciting, but still important items on the “to do” list are worth doing first for the benefit of our current and future patients, and our specialty. It is the goal of the OREBM Committee to continually support this pursuit for the otolaryngologist with educational endeavors, research activities, and emphasis of targeted areas within our specialty that are most in need of investigation. Annual Update on the Activities of the OREBM Committee The OREBM Committee has several ongoing and recently completed studies targeting important evidence gaps. Table 2* lists and provides an update on the status of these projects. As the committee strives to identify key evidence gaps, it is the goal that future projects, both of the OREBM Committee and the research sponsored by the Foundation CORE grants, will target these areas that will translate to a continually improving evidence basis on which to guide clinical decision-making. Online Exclusive Content Table 1. “To Do” List of Possible Prioritized Evidence Gaps Subspecialty Evidence Gap Pediatric Otolaryngology Diagnosis and management of residual obstructive sleep apnea after adenotonsillectomy to include use of sleep endoscopy and cine MRI Management of otitis media with effusion diagnosed in neonates within neonatal hearing screening programs Use of imaging in evaluation of hearing loss in children—MRI versus CT Benefits of proton pump inhibitor therapy in neonates with laryngomalacia/stridor Use of balloon dilation in the management of pediatric subglottic stenosis Rhinology Standardization of maximal medical therapy for chronic rhinosinusitis Accuracy of diagnosis of chronic rhinosinusitis in the primary care setting, e.g., family practice, internal medicine Development of a chronic rhinosinusitis treatment data registry Role of biofilms in chronic rhinosinusitis Laryngology Long-term compliance and benefits of voice therapy Effectiveness of antibiotic therapy in the setting of acute laryngitis Determination of which hoarse patients benefit most from proton pump inhibitor therapy Efficacy of Neurontin, Elavil, and/or Lyrica in treating chronic cough Utility of voice rest after vocal surgery Sleep Surgery Outcomes for nasal (and pharyngeal) surgery in improving long-term CPAP compliance Benefit of turbinoplasty in addition to adenotonsillectomy for management of pediatric obstructive sleep apnea Use of home sleep testing in a sleep surgical practice Outcomes for medical and surgical treatments for treatment of socially bothersome primary snoring Development of a sleep surgery data registry Table 2: Status Reports on the Ongoing Studies of the OREBM Committee Study Principal Investigator Open to Enrollment Status Hypopharyngeal Surgery in OSA: Practice Patterns, Perceptions, and Attitudes Eric J. Kezirian, MD, MPH University of California San Francisco, CA No This survey-based study aims to define factors that may be relevant to the surgical treatment of obstructive sleep apnea, with a specific focus on procedures used to treat hypopharyngeal or retrolingual obstruction. Surveys were distributed to Academy members meeting explicit eligibility criteria. Surveys distributed: 610 Surveys completed: 163 (27%) A manuscript for this survey-based study is currently under review at Otolaryngology—Head and Neck Surgery journal. Parent Response to Ear Disease in Children with and without Tubes (PREDICT) Quality of Life Research Study Judith E. C. Lieu, MD Washington University SOM St Louis, MO No This multi-institutional study has explored the effects that ear disease, in children ages 6 to 24 months, has on the children and their families in terms of quality of life. Forms distributed: 3,200 sets to 23 participating sites. Forms completed: 2,147 physician forms (67%) and 1,266 patient forms (40%). TALC (Treatment of Advanced Laryngeal Cancer) Study Bevan Yueh, MD, MPH University of Minnesota Minneapolis, MN Yes This is an observational multi-site study assessing how chemoradiation vs. laryngectomy affects quality of life, in particular, swallowing and speech. The focus will be evaluating the effects of chemoradiation and laryngectomy on patients with new tumors of the hypopharynx (T2, T3) and cartilage-invading larynx (T3, T4) that would require total laryngectomy for cure. Total enrolled: 144 patients Mean age: 60.5 Gender: Males (n=116) Females (n=28) Treatment group: Laryngectomy: n = 90 (62.5%) Chemoradiation: n = 53 (37%) Unknown: n = 1 (0.7%)
By Scott E. Brietzke, MD, MPH, OREBM Committee Chair
Which Chore to Do First?
The “dog days” of summer are upon us and that “to do” list of yard work is growing: fix the gate, paint the fence, plant that tree in the corner of the front yard. Let’s not kid ourselves, it’s all work, right? We would certainly take watching the game with the AC on in place of any of it. But if we are going to work in the yard on a Saturday afternoon, planting that tree (that the neighbors will surely notice) certainly sounds better than fixing that old gate and painting that fence.
For those who perform research, there is nothing greater than discovering something new and exciting, or publishing a paper on the “latest and greatest” thing everyone will be talking about. After all, who doesn’t want their work to be useful and interesting? But should the “latest and greatest” be what drives which research areas are pursued, instead of perhaps targeting the specific areas where new knowledge or data on comparative effectiveness would be more beneficial to our patients and our specialty? When winter comes around again and the leaves have fallen off the tree we planted (although, we did get some nice comments from the neighbors) we are sure going to wish we had made the time to paint that darn fence and fix that old gate!
The Outcomes Research and Evidence-Based Medicine (OREBM) Committee of the American Academy of Otolaryngology—Head and Neck Surgery Foundation strives to assist our specialty in this endeavor. Its formal stated charge is “to serve as a repository of expertise on health services research and evidence-based medicine, including outcomes and effectiveness research generally and specifically in otolaryngology-head and neck surgery; to advise and support other Academy and Foundation committees on outcomes and clinical effectiveness; to liaise with the Patient Safety and Quality Improvement Committee on research aspects of the development of clinical practice guidelines; to develop and maintain educational materials; instructional courses; and Annual Meeting miniseminars in these areas, including an Outcomes Primer; and to develop and maintain a prioritized list of project areas suitable for research on outcomes and clinical effectiveness.”
With this charge in mind, the OREBM aims to:
- Highlight relevant, current research data that can assist the otolaryngologist with patient decision-making and
- Guide research efforts into clinical areas that will most benefit our specialty based on identified gaps in evidence and emerging clinical importance.
Developing the ‘To Do’ List: Where Are the Evidence Gaps?
The OREBM Committee has spent considerable time pondering that issue for otolaryngology as a specialty. We have made it our task to reflect on our own practices and consider what areas are in most need of future data (i.e., evidence gaps) to help improve our evidence-based clinical decision-making. We developed a selected “to do” list of prioritized areas for future study in Table 1*. Note that only some areas of otolaryngology are listed—we are currently well represented with pediatric otolaryngologists, rhinologists, laryngologists, and sleep surgeons on the committee. We are in need of more neuro-otologists, head and neck surgeons, and facial plastic surgeons to join us. If this is your area of expertise and interest, please consider participation in the OREBM Committee. The more people who look around the “yard” the more complete our “to do” list will be and the better the “yard” will be.
In addition to pondering evidence gaps, the OREBM Committee has been considering and attempting to identify clinical areas that may benefit from compiling and critically analyzing the currently available data in the form of a systematic review or meta-analysis. These efforts may lead to future studies and/or help sharply develop clinical areas where true evidence gaps lie. The completion of a high-quality meta-analysis is not a simple task. Some committee members have been selected, after an academy-wide competitive search (anyone can apply), for sponsorship to attend the International Cochrane Collaboration Colloquium Meeting in October that will include training in advanced meta-analysis techniques. The requirement for receiving this support is a resulting submission of a completed meta-analysis for publication in Otolaryngology-Head and Neck Surgery. Thus, Academy members can expect to see more high-quality meta-analyses in our journal in the future.
How to Steer Research Effort into Targeted Areas?
Quality research requires talent, time, and financial support. The Academy and the OREBM Committee are exploring ways to tie financial support to study prioritized research areas for the benefit of future patients and our specialty as a whole. Stay tuned for more on this topic.
In conclusion, we hope you agree that even some of those less exciting, but still important items on the “to do” list are worth doing first for the benefit of our current and future patients, and our specialty. It is the goal of the OREBM Committee to continually support this pursuit for the otolaryngologist with educational endeavors, research activities, and emphasis of targeted areas within our specialty that are most in need of investigation.
Annual Update on the Activities of the OREBM Committee
The OREBM Committee has several ongoing and recently completed studies targeting important evidence gaps. Table 2* lists and provides an update on the status of these projects. As the committee strives to identify key evidence gaps, it is the goal that future projects, both of the OREBM Committee and the research sponsored by the Foundation CORE grants, will target these areas that will translate to a continually improving evidence basis on which to guide clinical decision-making.
Online Exclusive Content
Table 1. “To Do” List of Possible Prioritized Evidence Gaps
Subspecialty | Evidence Gap |
---|---|
Pediatric Otolaryngology |
|
Rhinology |
|
Laryngology |
|
Sleep Surgery |
|
Table 2: Status Reports on the Ongoing Studies of the OREBM Committee
Study | Principal Investigator | Open to Enrollment | Status |
---|---|---|---|
Hypopharyngeal Surgery in OSA: Practice Patterns, Perceptions, and Attitudes | Eric J. Kezirian, MD, MPH University of California San Francisco, CA |
No | This survey-based study aims to define factors that may be relevant to the surgical treatment of obstructive sleep apnea, with a specific focus on procedures used to treat hypopharyngeal or retrolingual obstruction. Surveys were distributed to Academy members meeting explicit eligibility criteria. Surveys distributed: 610 Surveys completed: 163 (27%) A manuscript for this survey-based study is currently under review at Otolaryngology—Head and Neck Surgery journal. |
Parent Response to Ear Disease in Children with and without Tubes (PREDICT) Quality of Life Research Study | Judith E. C. Lieu, MD Washington University SOM St Louis, MO |
No | This multi-institutional study has explored the effects that ear disease, in children ages 6 to 24 months, has on the children and their families in terms of quality of life. Forms distributed: 3,200 sets to 23 participating sites. Forms completed: 2,147 physician forms (67%) and 1,266 patient forms (40%). |
TALC (Treatment of Advanced Laryngeal Cancer) Study | Bevan Yueh, MD, MPH University of Minnesota Minneapolis, MN |
Yes | This is an observational multi-site study assessing how chemoradiation vs. laryngectomy affects quality of life, in particular, swallowing and speech. The focus will be evaluating the effects of chemoradiation and laryngectomy on patients with new tumors of the hypopharynx (T2, T3) and cartilage-invading larynx (T3, T4) that would require total laryngectomy for cure. Total enrolled: 144 patients Mean age: 60.5 Gender: Males (n=116) Females (n=28) Treatment group: Laryngectomy: n = 90 (62.5%) Chemoradiation: n = 53 (37%) Unknown: n = 1 (0.7%) |