Laryngectomy and Laryngeal Cancer: A Fascinating and Inspiring Chapter in the Expansion of Otolaryngology
Valerie A. Fritsch, MD Medical University of South Carolina, Charleston Once a universally fatal diagnosis, “epithelioid” carcinoma of the larynx has evolved during the past 150 years into one of the most curable cancers. A historical overview of the diagnosis and surgical management of laryngeal carcinoma shows how this disease became the cornerstone of otolaryngology cancer care. Highlights include important contributions, such as Billroth’s first total laryngectomy in 1873, and Gluck and Cohen’s modified version (1884), which involved completely separating the trachea and pharynx to reduce the risk of post-operative aspiration. Still, at the turn of the 19th century, operative and peri-operative mortality rates were reportedly as high as 50 percent and the procedure was nearly abandoned. Fortunately, rapid biomedical and technologic advances during that time eventually lifted many of the initial limitations. The evolution of laryngoscopy, tracheostomy, neck dissection, and reconstructive surgery, as well as the availability of antibiotics, endotracheal anesthesia, intravenous access, and blood replacement led to a resurgence of radical surgical extirpation in the 1940s. The role of otolaryngologists in improving diagnostic techniques and surgical approaches and reconstruction was key. Since the latter half of the last century, efforts have focused on refining more advanced techniques to improve voice and swallowing outcomes, while maintaining or improving oncologic outcomes. In addition, an increased understanding of the molecular basis of cancer has catalyzed a significant interest in individualized, targeted therapies. Although the prognosis of laryngeal carcinoma remains far from “favorable” by today’s standards, the astoundingly rapid advances of knowledge and technology by our innovative predecessors illustrates the unbounded potential for future discoveries and improvements in our understanding and management of this complex disease. Otolaryngology Historical Society Call for Papers If you are interested in presenting at the next OHS meeting, which will take place Sept. 30 in Vancouver, BC, Canada, email museum@entnet.org.To join the society or renew your membership, please check the box on your Academy dues invoice or email Catherine R. Lincoln, CAE, MA (Oxon) at clincoln@entnet.org or call 1-703-535-3738.
Valerie A. Fritsch, MD
Medical University of South Carolina, Charleston
Once a universally fatal diagnosis, “epithelioid” carcinoma of the larynx has evolved during the past 150 years into one of the most curable cancers. A historical overview of the diagnosis and surgical management of laryngeal carcinoma shows how this disease became the cornerstone of otolaryngology cancer care.
Highlights include important contributions, such as Billroth’s first total laryngectomy in 1873, and Gluck and Cohen’s modified version (1884), which involved completely separating the trachea and pharynx to reduce the risk of post-operative aspiration. Still, at the turn of the 19th century, operative and
peri-operative mortality rates were reportedly as high as 50 percent and the procedure was nearly abandoned. Fortunately, rapid biomedical and technologic advances during that time eventually lifted many of the initial limitations. The evolution of laryngoscopy, tracheostomy, neck dissection, and
reconstructive surgery, as well as the availability of antibiotics, endotracheal anesthesia, intravenous access, and blood replacement led to a resurgence of radical surgical extirpation in the 1940s.
The role of otolaryngologists in improving diagnostic techniques and surgical approaches and reconstruction was key. Since the latter half of the last century, efforts have focused on refining more advanced techniques to improve voice and swallowing outcomes, while maintaining or improving oncologic outcomes.
Otolaryngology Historical Society Call for Papers